CDC is issuing new guidance to clinicians for the treatment of severe malaria cases in the United States (U.S.). This change in treatment protocol is necessary because the only FDA-approved intravenous (IV) antimalarial drug in the U.S., quinidine, has been discontinued by the manufacturer and will no longer be available. As of April 2019, artesunate, the WHO-recommended first-line treatment of severe malaria, will become the first-line treatment for severe malaria in the U.S.
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