Cancer is the second leading cause of death worldwide. In 2012, more than 14 million new cases of cancer were diagnosed around the world. That number is expected to reach 19 million by 2025. We could prevent at least one-third of the 8 million annual cancer deaths through screening tests, vaccinations, and lifestyle changes such as quitting smoking. CDC is working with partners to improve coordination of cancer prevention and control programs globally and reduce the cancer burden in low- and middle- income countries.